
Entry	Additives	Solvent	Time h	Temp. ˚C	Yield (%)^b
Optimization of reaction conditions for the synthesis of nitrile
1	PTSA	MeCN	10	80	82
2	TfOH	MeCN	10	80	84
3	CH₃SO₃H	MeCN	10	80	77
4	AcOH	MeCN	10	80	58
5	TFA	MeCN	10	80	71
6	TsCl	MeCN	10	80	86
7	Na₂SO₄	MeCN	10	80	NR^C
8	TsCl	THF	24	80	trace
9	TsCl	Toluene	8	100	92
10	TsCl	Dioxane	24	100	trace
11	TsCl	DMF	24	110	41
12	TsCl	--	6	100	94
Optimization of reaction conditions for the synthesis of amide
13	--	Toluene	10	100	75
14	--	MeCN	10	90	51
15	--	DCE	10	100	43
16	--	--	4	100	88