Uncomplicated malaria

· Artemether/lumefantrine

· Dihydroartemisinin/piperaquine

· Alternative: Quinine

Uncomplicated malaria in the first trimester of pregnancy

· Quinine/clindamycin

Mixed infections

· Artemether/lumefantrine, Dihydroartemisinin/piperaquine

· Anti-relapse treatment with primaquine can be given for 14 days if P. malariae is confirmed in a mixed infection

Treatment failure

· Quinine tablets

Pre-referral treatment for complicated malaria

· Artesunate injection,

· Rectal artesunate at the community level

Complicated malaria

· Injectable artesunate

· Alternatives: Artemether (intramuscular [IM]) or quinine (intravenous [IV]/IM)

Malaria Prophylaxis

· Sickle cell disease—Pyrimethamine/dapsone

· Visitors (non-immunes) to Zambia—mefloquine, atovaquone-proguanil and doxycycline

Intermittent Presumptive Treatment in pregnancy

· Sulfadoxine/pyrimethamine