Subjects

dose (mean ± sd)

50 mg

100 mg

200 mg

400 mg

C_max (μg/ml)

2.76 ± 0.574

4.86 ± 0.561

10.9 ± 2.17

22.7 ± 3.59

t_1/2 ( h)

133 ± 6.62

146 ± 3.82

125 ± 13.0

129 ± 18.6

AUC (μg∙hr/mL)

145 ± 20.4

254 ± 22.9

592 ± 66.8

1160 ± 170

CL (L/h)

0.225 ± 0.0378

0.240 ± 0.0196

0.219 ± 0.0230

0.226 ± 0.0421