| Parameter | Normal (n = 9) | Renal Impairment | End-stage renal disease | ||||
| Mild (n = 6) | Moderate (n = 6) | Severe (n = 6) | Severe (n = 4) | Predialysis (n = 3) | Postdialysis (n = 3) | ||
| Dose (mg/d) | 1000 | 1000 | 1000 | 500 | 1000 | 500 | 500 |
| CL (L/h) | 0.042 ± 0.008 | 0.038 ± 0.005 | 0.027 ± 0.005 | 0.022 ± 0.006 | 0.024 ± 0.007 | 0.026 ± 0.006 | 0.035 ± 0.011 |