| Parameter | Normal (n = 9) | Hepatic Impairment | ||
| Mild (n = 6) | Moderate (n = 6) | Severe (n = 5) | ||
| Dose (mg/d) | 1000 | 1000 | 1000 | 1000 |
| CL (L/h) | 0.047 ± 0.011 | 0.047 ± 0.008 | 0.065 ± 0.010 | 0.074 ± 0.020 |