| Placebo | Test product | ||
| Day 1 | Day 29 | Day 1 | Day 29 |
Plasma renin activity, ng/ml/h |
|
|
|
|
Baseline (0 h) | 0.65 ± 0.08 | 0.69 ± 0.15 | 0.63 ± 0.12 | 0.55 ± 0.09 |
2.5 h | 0.74 ± 0.12 | 0.85 ± 0.18 | 0.76 ± 0.10 | 0.63 ± 0.14 |
5 h | 0.80 ± 0.08 | 0.69 ± 0.17 | 0.67 ± 0.11 | 0.45 ± 0.12 |
9 h | 0.61 ± 0.11 | 0.61 ± 0.10 | 0.58 ± 0.09 | 0.53 ± 0.10 |
Plasma trapping ACE activity, fmol/ml/min |
|
|
|
|
Baseline | 429 ± 22 | 421 ± 23 | 418 ± 25 | 431 ± 26 |
2.5 h | 439 ± 24 | 414 ± 35 | 440 ± 30 | 446 ± 30 |
5 h | 434 ± 22 | 436 ± 23 | 442 ± 22 | 451 ± 25 |
9 h | 417 ± 23 | 432 ± 23 | 421 ± 26 | 435 ± 26 |
Plasma aldosterone, pg/ml |
|
|
|
|
Baseline | 50.8 ± 3.4 | 54.8 ± 4.8 | 49.5 ± 3.4 | 52.6 ± 4.2 |
2.5 h | 67.7 ± 8.3 | 65.4 ± 10.4 | 68.4 ± 8.7 | 60.2 ± 5.0 |
5 h | 49.1 ± 3.9 | 46.4 ± 4.4 | 50.0 ± 7.3 | 45.8 ± 4.3 |
9 h | 45.6 ± 4.1 | 46.6 ± 4.7 | 53.4 ± 7.2 | 61.8 ± 8.3 |