Authors	Study Design	Sample Size (N)	Instrument	Main Finding	Potential Clinical Application
Oberbaum et al. [8]	Randomized, placebo-controlled, double blind	N = 32	WHO grading for mucositis	Traumeel S reduces duration and severity of stomatitis	Efficacy in treating stomatitis in patients with chemotherapy
Sencer et al. [20]	Randomized, placebo-controlled, double blind	N = 195	Three-grade modified Walsh scale for mucositis; WHO Oral toxicity Scale	No difference in treatment of stomatitis	Unknown
Porozov et al. [29]	In vitro	N = 24	IL-1B, TNFa and IL-8	Traumeel lowers levels of IL-1B, TNF-a and IL-8	Inhibit chronic inflammation
Pilat et al. [7]	Randomized, placebo-controlled, double blind	N = 40	IL-6 and hsCRP	Trammel lowered leukocytosis and neutrocytosis, but not IL-6 and hsCRP	Unknown
Gonzalez de Vega et al. [6]	Randomized, controlled study	N = 449	VAS and FAAM scores	No difference in pain improvement in epicondylitis	Alternative therapy for orthopedic injury
Birnesser et al. [19]	Observational, non-randomized study	N = 184	Questionnaire with “good” or “very good” response	Trameel S reduces pain and increases mobility in epicondylitis	Alternative therapy for orthopedic injury
Bohmer et al. [26]	Controlled, double-blind study	N = 102	Swelling and skin temperature	Trameel S reduces swelling and skin temperature following injury	Efficacy in treating soft tissue injury
Schneider et al. [5]	Observational cohort study	N = 133	3 point scale of pain reporting	No difference in pain improvement following trauma and injuries	Unknown
Singer et al. [31]	Randomized double blind placebo study	N = 80	11-point numerical rating pain score	No difference in pain improvement following orthopedic surgery following Traumeel S administration	Unknown
Zilinskas et al. [30]	In vitro	N = 43	Leukocyte count and the Antioxidant capacity of the blood and serum	Increase in antioxidant activity in blood, but increase in leukocyte count in patients with periodontitis following Traumeel S administration	Unknown