| Event | All grades | Grade III/IV | ||||
| Cumulative dose < 400 mg/m2 (n = 50) | Cumulative dose ≥ 400 mg/m2 (n = 31) | P values | Cumulative dose < 400 mg/m2 (n = 50) | Cumulative dose ≥ 400 mg/m2 (n = 31) | p values | |
| Number (%) | Number (%) | Number (%) | Number (%) | |||
| Non-hematological | ||||||
| Decline in LVEF | 1 (2.0) | 2 (6.5) | 0.555 | 0 (0.0) | 0 (0.0) | NA |
| Congestive heart failure | 1 (2.0) | 2 (6.5) | 0.555 | 0 (0.0) | 0 (0.0) | NA |
| PPE | 8 (16.0) | 12 (38.7) | 0.021 | 1 (2.0) | 5 (16.1) | 0.028 |
| Stomatitis | 8 (16.0) | 10 (32.3) | 0.087 | 3 (6.0) | 7 (22.6) | 0.039 |
| Mucositis | 6 (12.0) | 7 (22.6) | 0.207 | 2 (4.0) | 3 (9.7) | 0.366 |
| Diarrhea | 6 (12.0) | 7 (22.6) | 0.207 | 3 (6.0) | 2 (6.5) | 1.000 |
| Constipation | 2 (4.0) | 6 (19.4) | 0.049 | 0 (0.0) | 0 (0.0) | NA |
| Anorexia | 3 (6.0) | 10 (32.3) | 0.004 | 1 (2.0) | 5 (16.1) | 0.028 |
| Nausea | 10 (20.0) | 11 (35.5) | 0.122 | 4 (8.0) | 5 (16.1) | 0.293 |
| Vomiting | 5 (10.0) | 8 (25.8) | 0.060 | 1 (2.0) | 4 (12.9) | 0.068 |
| Fatigue | 4 (8.0) | 10 (32.3) | 0.007 | 2 (4.0) | 5 (16.1) | 0.100 |
| Hematological |
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| Anemia | 8 (16.0) | 8 (25.8) | 0.281 | 2 (4.0) | 4 (12.9) | 0.196 |
| Leukopenia | 4 (8.0) | 9 (29.0) | 0.026 | 3 (6.0) | 4 (12.9) | 0.419 |
| Neutropenia | 3 (6.0) | 5 (16.1) | 0.249 | 0 (0.0) | 4 (12.9) | 0.019 |
| Thrombocytopenia | 6 (12.0) | 6 (19.4) | 0.365 | 2 (4.0) | 2 (6.5) | 0.635 |