Obesity

Not obese

Obese

48

33

59.3

40.7

ECOG PS

0, I

II

5

76

6.2

93.8

Prior trastuzumab

Yes

No

17

64

21.0

79.0

Prior locoregional radiotherapy to left breast

Yes

No

21

60

25.9

74.1

Prior anthracycline-based regimen

Doxorubicin-based

Epirubicin-based

32

49

39.5

60.5

Cumulative dose of priordoxorubicin

Mean ± SD

253.1 ± 25.2

Cumulative dose of prior epirubicin

Mean ± SD

588.0 ± 97.3

Number of PLD cycles

Mean (Range)

7.57 (2 - 24)

Cumulative dose of PLD (mg/m2)

Mean ± SD

Range

378.4 ± 250.2

100 - 1200

High PLD cumulative dose (≥400 mg/m2)

Yes

No

31

50

38.3

61.7