First author (year)

Country

Characteristics of participants

Diagnosis of MCI

Oral microbiome sampling

Study type

Results

Da et al. (2023)

China

MCI = 47

Cognitively normal = 47

Male = 46

Mean age = 73.58 ± 5.25 yo

Peterson criteria

Non-stimulated saliva

Case-control

Gemella haemolysans and Streptococcus gordonii were lower while Veillonella unclassified_Veillonella and Fusobacterium sp._HMT_203 were higher in MCI

Holmer et al.

(2021)

Sweden

AD = 46

MCI = 40

Subjective cognitive normal = 46

Cognitively healthy = 63

Age = 50 - 80 yo

Winblad

criteria

Deepest periodontal pocket

Case-control

Treponema, Prevotella, Campylobacter were higher in MCI

Rothia aeria, Corynebacterium durum and several members of Actinomycesgenus were lower

Batthini et al.

(2020)

Switzerland

Participant = 78

MMSE, chemosensory and CDR

Non-stimulated saliva

Cohort

Depletion of bacterial taxa in MCI

Prevotella tannerae, Filifactor alocis and Porphyromonas gingivalis decreased in MCI

Cardiobacterium valvarum is increased

Yang et al.

(2020)

United States of America

MCI = 34

Control = 34

Male = 27

All components of UDS

Soft tissue oral swab

Cohort

Pasteurellacae family were more abundant in MCI and Lautropia Mirabilis lower