First author (year) | Country | Characteristics of participants | Diagnosis of MCI | Oral microbiome sampling | Study type | Results |
Da et al. (2023) | China | MCI = 47 Cognitively normal = 47 Male = 46 Mean age = 73.58 ± 5.25 yo | Peterson criteria | Non-stimulated saliva | Case-control | Gemella haemolysans and Streptococcus gordonii were lower while Veillonella unclassified_Veillonella and Fusobacterium sp._HMT_203 were higher in MCI |
Holmer et al. (2021) | Sweden | AD = 46 MCI = 40 Subjective cognitive normal = 46 Cognitively healthy = 63 Age = 50 - 80 yo | Winblad criteria | Deepest periodontal pocket | Case-control | Treponema, Prevotella, Campylobacter were higher in MCI Rothia aeria, Corynebacterium durum and several members of Actinomycesgenus were lower |
Batthini et al. (2020) | Switzerland | Participant = 78 | MMSE, chemosensory and CDR | Non-stimulated saliva | Cohort | Depletion of bacterial taxa in MCI Prevotella tannerae, Filifactor alocis and Porphyromonas gingivalis decreased in MCI Cardiobacterium valvarum is increased |
Yang et al. (2020) | United States of America | MCI = 34 Control = 34 Male = 27 | All components of UDS | Soft tissue oral swab | Cohort | Pasteurellacae family were more abundant in MCI and Lautropia Mirabilis lower |