Phases of stress onset	Social and behavioral domain	Individual psychological domain	Physiology domain
Phases of stress onset	Social and behavioral domain	Individual psychological domain	Live organism response level	Immune response level
1	Situational uncertainty regarding social risk factors	Primary shock response to the damaging effects	Fast adaptation preparation of the system and resource mobilization	Immediate phase nonspecific (congenital) protection mechanisms
2	Sampling of possibilities Within different aspects of social situation	Alarm stage general undirected activity	Transient adaptation transient period: from fast to long-term adaptation mechanisms	Early phase switching to different specific response mechanisms
3	Forming the intentions choosing adequate vector of activities	Resistance stage mobilization of the energy and structural resources of live organism	Long-term adaptation activation of structural homeostatic mechanisms, active functioning under new conditions	Late phase Switching of the antibody synthesis from IgM to IgG
4	Reduction of social activity	Exhaustion state (distress) apathy, tiredness, depression-lake states etc.	Exhaustion of the protective and adaptation capacity maximal loading of the dominating systems in process of adaptation	Completeness of the immune response Immunological memory formation