Predicted Means (SE)

Metric

OM¹

MM²

EM³

SM⁴

Half-life⁵ (h)

56.8^ab (21.7)**

136.0^b (26.6)

85.2^ab (21.7)

36.3^a (21.7)

Cmax⁶

4.3^a (0.4)

3.7^a (0.4)

3.9^a (0.4)

2.1^b (0.4)

Tmax⁷

13.3^a (4.0)

10.7^a (4.0)

13.3^a (4.0)

2.7^b* (4.0)

AUC_0-t⁸

224.8^a (12.6)

227.4^a (12.7)

208.1^a (12.4)

95.8^b (12.4)

AUC_0-∞^9**

383.4^ab (126.8)

877.8^b (155.3)

457.1^ab (126.8)

126.4^a (126.8)