With ROSE	Without ROSE
Protocol (guideline)	Individual procedures according to the operator
Defined quality control	No quality control or individual quality control
Guarantee of adequate material	Indefinite adequacy
No repeated collections	Possible repeated collections and in conclusion
Higher cellular detail	Lower cellular detail
Reliable cytopathological classification	Low reliability in cytopathological classification
Initial evaluation	No initial evaluation
Allows interprofessional interaction	No interprofessional interaction
Saves resources and time	Higher costs due to repeated procedures and in conclusion