COMPOUNDS

ANTIDIABETIC CLASS

MOLECULAR WEIGHT (G/MOLE)

BINDING ENERGY (KCAL/MOLE)

LOG P

DRUG LIKLINESS

COMPOUND NUMBER

Glibenclamide

Sulfonylureas

494.004

−7.7

4.7

YES

A

Glimepiride

Sulfonylureas

490.617

−7.7

3.81

YES

B

Glipizide

Sulfonylureas

445.536

−7.6

1.91

YES

C

Repaglinide

Meglitinides

452.586

−6.7

3.97

YES

D

Metformin

Biguanides

129.164

−3.9

0.35

YES

E

Saxagliptin

dipeptidyl peptidase4 inhibitors

333.432

−6.5

0.88

YES

F

Pioglitazone

Thiazolidinedione

356.44

−6.5

3.46

YES

G

Acarbose

Alpha-glucosidase inhibitors

645.604

−5.6

-8.5

YES

H

Canagliflozin

SGLT-2 inhibitors

444.52

−7.5

3.44

YES

I

Sitagliptin

dipeptidyl peptidase4 inhibitors

407.314

−7.0

1.26

YES

J

Linagliptin

dipeptidyl peptidase4 inhibitors

472.54

−7.2

3.92

YES

K

Miglitol

Alpha-glucosidase inhibitors

207.224

−4.1

-2.29

YES

L

Rosiglitazone

Thiazolidinediones

357.428

−6.5

1.8

YES

M

Vildagliptin

dipeptidyl peptidase4 inhibitors

303.399

−6.1

1.12

YES

N

CONTROL

Natural organic acid (methyl 3,4 di-O-caffeoylquinic acid

530.5

−6.2

1.9

YES

O