Impurity Code | Impurity Name | Chemical Name | Chemical Structure | RT in LCMS |
MGI-1 | β-Methyldiazo Azetidinone | (4-Nitrophenyl)methyl (γR,2R,3S)-α-diazo-3- [(1R)-1-hydroxyethyl]-γ-methyl-β, 4-dioxo-2-azetidinebutanoate |
| 19.668 |
MGI-2 | β-Methyl Azetidinone | (R)-2-((2S,3S)-3-((R)-1- ((tert-butyldimethylsilyl)oxy)ethyl)-4- oxoazetidin-2-yl)propanoic acid |
| 20.237 |
MGI-3 | Dihydrobenzoxazinone | Spiro[benzo[e][1,3]oxazine-2,1’- cyclohexan]-4(3H)-one |
| 22.050 |
MGI-4 | 4-Acetoxy Azetidinone | (2R,3R)-3-((R)-1- ((tert-butyldimethylsilyl)oxy)ethyl)-4- oxoazetidin-2-yl acetate |
| 23.850 |
MGI-5 | Thiolactone | (1S,4S)-5-(4-nitrobenzyloxy-carbonyl)-2- thia-5-azabicyclo[2.2.1]heptane-3-one |
| 24.515 |
MGI-6 | Azetidinone Malonate Ester | (4-nitrophenyl)methyl (γR,2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl) dimethylsilyl]oxy]ethyl]-γ-methyl-β, 4-dioxo-2-azetidine butanoate |
| 32.387 |
MGI-7 | Diprotected Meropenem | 4R,5S,6S)-4-nitrobenzyl 3-((3S,5S)- 1-((4-nitrobenzyloxy)carbonyl)-5-(dimethylcarbamoyl)pyrrolidin-3-ylthio)-6- ((R)-1-hydroxyethyl)-4-methyl-7-oxo-1- aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate |
| 32.550 |
MGI-8 | Silylated β-Methyl diazo Azetidinone | 4-nitrobenzyl (R)-4-((2R,3S)-3-((R)-1- ((tert-butyldimethylsilyl)oxy)ethyl)-4- oxoazetidin-2-yl)-2-diazo-3- oxopentanoate |
| 34.096 |
MGI-9 | 2-Chlorodihydro Benzoxazinone | 3-(2-chloropropanoyl)spiro[benzo[e][1,3]oxazine-2,1’-cyclohexan]-4(3H)-one |
| 34.734 |
MGI-10 | 2-Bromodihydro Benzoxazinone | 3-(2-bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1’-cyclohexan]-4(3H)-one |
| 35.561 |