Conditions applied for the standard solution | Time (h) | % of active drug present after degradation ±RSD | |
Metformin | Saxagliptin | ||
0.1 N HCl at 80˚C temp | 1 | 75.29 ± 1.7 | 73.87 ± 1.5 |
1 N HCl at 80˚C temp | 1 | 78.34 ± 1.9 | 75.86 ± 2.1 |
0.1 N NaOH at 80˚C temp | 1 | 67.69 ± 1.8 | 42.87 ± 1.3 |
3% H2O2 | 1 | 81.43 ± 1.2 | 76.64 ± 1.3 |
Photolytic degradation (sunlight) | 24 | 88.96 ± 1.6 | 90.34 ± 1.4 |