Author/Year

Design

N

Population

Country

Outcome (ADHD)

1) Roigé-Castellví, J. (2020) [23]

Cross-sectional study

6720

Children from General population

Spain

Association of prenatal and perinatal factors, such as metabolic disorder in the pregnancy, difficulties in childbirth and specific family phenotype (expression of the genetic risk) with childhood ADHD

2) Markussen Linnet, K. (2006) [25]

Follow-up study

1355

Singletons born from mothers who smoking during pregnancy

Denmark

60% increased risk of hyperactivity in children born from mothers who smoke

3) Gustavson, K. (2017) [29]

Cohort study

N > 100,000

Children born from mothers who smoking during pregnancy

Norway

Smoking during pregnancy is an unmeasured confounding

4) Parvaresh, N. (2016) [31]

Case-control

study

200

Parents of 7 to 12 year-old children who referred to child and adolescent psychiatric clinics

Iran

A higher frequency of substance abuse, smoking, and anxiety disorders was observed among parents of children suffering from ADHD

5) Rodriguez, A.

(2005) [33]

Cohort study

414

Children born from mothers who smoking and who had stress during pregnancy

Sweden

Prenatal exposure to stress was independently associated with later symptoms of ADHD. Results are less clear for smoking

6) Ronald, A. (2011) [34]

Cohort study

2900

Children born from mothers who had stress during pregnancy

UK

Stressful life events are associated with autistic traits as well as ADHD behaviors independently

7) Pagnin, D. (2019) [40]

Cohort study

449

Children born from mothers who used alcohol during pregnancy

Brazil

Binge drinking at any time during pregnancy or low-moderate alcohol consumption in all trimesters of pregnancy was associated with fivefold increased odds of child ADHD

8) Mick, E. (2002) [43]

Case-control

study

522

Children born from mothers who used alcohol, drugs and smoking during pregnancy

USA

ADHD may be an additional deleterious outcome associated with prenatal exposure to alcohol independently of the association between prenatal exposure to nicotine and smoke products and other familial risk factors for the disorder

9) Sagiv, S. (2013) [44]

Cohort study

604

Children who exposed to perinatal risk factors

USA

Low paternal education, prenatal smoking, prenatal illicit drug use, maternal depression, were associated with greater risk for ADHD

10) Eilertsen, E. (2017) [46]

Cohort study

114,247

Children born from mothers who measured from using alcohol during pregnancy

Norway

Possibly causal association with maternal alcohol use during pregnancy, but no such effect was observed for clinical ADHD diagnosis

11) Soltanifar, A.

(2009) [48]

Cohort study

50

Mothers of children who have ADHD

Iran

The Intensity of depression and trait anxiety in mothers of ADHD children are more than the control group