Insulin name (Brand)

Onset (hours)

Peak (hours)

Duration (hours)

Rapid acting

Lispro (Humalog)

~0.25

0.5 - 2.5

≤5

Aspart (Novolog)

~0.25

1 - 3

3 - 5

Glulisine (Apidra)

~0.25

1.6 - 2.8

3 - 4

Human insulin inhalation powder (Afrezza)

~0.25

~1

2.5 - 3

Short acting

Regular (Novolin R or Humulin R)

0.5 - 1

2.5 - 5

4 - 12

Intermediate acting

NPH (Novolin N or Humulin N)

1 - 2

4 - 12

14 - 24

Long acting

Glargine(Lantus)100 units/mL

3 - 4

None

>24

Glargine(Toujeo) 300 units/mL

6

None

24 - 36

Detemir (Levemir)

3 - 4

3 - 9

Dose dependent 6 - 23

Degludec(Tresiba)100 units/ml; 200 units/ml

3 - 4

None

>42

Combination products

70/30 NPH/regular (Humulin or Novolin)

0.5 - 1

2 - 12

18 - 24

70/30 NPH/aspart (Novolog Mix)

~0.25

~1 - 4

18-24

75/25 NPH/lispro or 50/50 NPH/lispro (Humalog Mix)

~0.25

~1 - 5

14 - 24

70/30Degludec/aspart (Ryzodeg)

~0.25

~1 - 4

>42

Concentrated insulin

U-500 regular (Humulin R U-500)

0.5 - 1

2.5 - 5

Up to 24