All subjects

n = 83

High FeNO

n = 24

Low FeNO

n = 59

p-value

Age, years

72.6 ± 6.3

73.6 ± 6.8

72.7 ± 6.1

0.341

Gender, male/female

76/7

23/1

53/6

0.667

Body mass index, kg/m²

21.9 ± 3.8

21.7 ± 4.2

22.0 ± 3.7

0.738

Pack-years

56.9 ± 30.6

63.5 ± 36.7

54.3 ± 27.7

0.218

History of allergic rhinitis, n

9

2

7

0.999

History of asthma, n

5

2

3

0.624

Atopy, n

25

9

16

0.999

Treatment, LAMA/LAMA+LABA

28/55

9/15

19/40

0.798

FeNO, ppb

29.7 ± 26.4

58.7 ± 32.7

18.0 ± 8.6

<0.001

Blood eosinophil counts, /μL

209.6 ± 126.1

287.6 ± 166.2

181.4 ± 87.8

<0.001

Blood eosinophil counts > 300/μL, n

16

11

5

<0.001

IgE, IU/ml

269.2 ± 520.3

401.2 ± 675.3

199.9 ± 410.3

0.153

Atopy, n

25

9

16

0.999

mMRC 0/1/2/3/4, n

10/45/21/7/0

5/12/5/2/0

5/32/16/5/0

−

CAT

10.6 ± 7.3

10.5 ± 7.9

10.6 ± 7.1

0.972

GOLD 1/2/3/4, n

20/38/15/10

5/15/2/2

15/23/13/8

−

%FVC, %

93.1 ± 23.2

93.3 ± 26.9

93.0 ± 21.7

0.967

%FEV1, %

61.6 ± 22.4

63.9 ± 18.4

60.7 ± 23.9

0.547

FEV1/FVC, %

52.6 ± 14.4

56.1 ± 14.8

51.2 ± 14.1

0.159

IC, L

2.01 ± 0.61

2.14 ± 0.68

1.95 ± 0.57

0.191

Reversibility

>12% and >200 ml, n

5

2

3

0.639

>12%, n

9

2

7

0.466

Absolute change, ml

72.1 ± 86.6

74.7 ± 106.7

70.8 ± 75.9

0.874

% change, %

5.9 ± 8.4

5.0 ± 8.1

6.4 ± 8.6

0.732

R5, cmH₂O/L/s

3.57 ± 1.55

2.98 ± 1.42

3.81 ± 1.55

0.027

R20, cmH₂O/L/s

2.64 ± 0.98

2.30 ± 0.94

2.78 ± 0.96

0.041

R5 - R20, cmH₂O/L/s

0.92 ± 0.64

0.69 ± 0.53

1.02 ± 0.67

0.034

X5, cmH₂O/L/s

−1.33 ± 1.30

−0.83 ± 0.84

−1.55 ± 1.41

0.024

Fres, Hz

12.45 ± 5.63

10.67 ± 4.51

13.20 ± 5.91

0.065

ALX, cmH₂O/L/s × Hz

9.60 ± 11.90

5.19 ± 6.81

11.40 ± 13.10

0.031