| Dobesilate OD group | Graduation | Consequence on treatment | Dobesilate BID group | Graduation | Consequence on treatment |
| Headache | Moderate | Not suspended | Therapeutic failure | Moderate | Suspended |
| Arthritis | Mild | Not suspended | Malaise | Moderate | Suspended |
| Hemorrhoids | Mild | Not suspended | Malaise | Moderate | Suspended |
| Skin rash | Mild | Not suspended | Gastric discomfort | Moderate | Suspended |