| Dobesilato OD | Dobesilato BID | ||||||||||||||||
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| Day 0 | 2 weeks | 4 weeks | 8 weeks | Day 0 | 2 weeks | 4 weeks | 8 weeks | |||||||||
| Pain | 5.4 ± 2.7 | 3.2 ± 2.0 | 2.1 ± 1.6 | 1.3 ± 1.8 | 5.5 ± 2.3 | 3.5 ± 2.0 | 2.8 ± 1.8 | 2.0 ± 1.6 | |||||||||
| p intra groups |
| 0.00 | 0.00 | 0.00 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups | 0.99 | 0.40 | 0.04 | 0.02 |
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| Paresthesia | 5.0 ± 2.8 | 2.9 ± 2.1 | 1.8 ± 1.6 | 1.1 ± 1.3 | 5.0 ± 2.5 | 3.0 ± 2.1 | 2.2 ± 1.9 | 1.3 ± 1.5 | |||||||||
| p intra groups* |
| 0.00 | 0.00 | 0.00 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups** | 0.92 | 0.95 | 0.22 | 0.33 |
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| Edema | 4.6 ± 3.2 | 2.8 ± 2.6 | 2.0 ± 2.2 | 1.4 ± 1.8 | 4.3 ± 2.9 | 2.6 ± 2.3 | 1.9 ± 1.9 | 1.2 ± 1.6 | |||||||||
| p intra groups* |
| 0.00 | 0.00 | 0.02 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups** | 0.54 | 0.84 | 0.75 | 0.94 |
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| Cramps | 5.4 ± 3.1 | 2.8 ± 2.4 | 1.9 ± 1.8 | 1.2 ± 1.6 | 5.7 ± 3.0 | 3.3 ± 2.4 | 2.6 ± 2.2 | 1.6 ± 1.9 | |||||||||
| p intra groups* |
| 0.00 | 0.00 | 0.00 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups** | 0.69 | 0.16 | 0.13 | 0.46 |
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| Heaviness | 6.2 ± 2.7 | 4.2 ± 2.2 | 2.6 ± 2.0 | 1.7 ± 2.0 | 6.1 ± 2.7 | 3.9 ± 2.4 | 3.0 ± 2.2 | 2.2 ± 2.1 | |||||||||
| p intra groups* |
| 0.00 | 0.00 | 0.00 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups** | 0.83 | 0.79 | 0.23 | 0.10 |
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| Total | 26.4 ± 10.5 | 15.8 ± 7.8 | 10.2 ± 6.4 | 5.0 ± 6.3 | 26.5 ± 9.2 | 15.8 ± 8.8 | 11.5 ± 8.2 | 7.1 ± 7.4 | |||||||||
| p intra groups* |
| 0.00 | 0.00 | 0.00 |
| 0.00 | 0.00 | 0.00 | |||||||||
| p between groups** | 0.80 | 0.77 | 0.38 | 0.05 |
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