Variable

Dobesilato OD

p intra groups

Dobesilato BID

p intra

groups

P between groups

SAP mmHg

Day 0

111.9 ± 11.5

112.6 ± 12.2

0.66^**

2 weeks

112.1 ± 9.3

0.68^*

113.5 ± 11.2

0.89^*

0.72^**

4 weeks

111.0 15.8

0.46^*

114.2 ± 10.4

0.56^*

0.16^**

8 weeks

113.8 ± 7.3

0.14^*

112.1 ± 9.7

0.20^*

0.57^**

DAP mmHg

Day 0

71.2 ± 9.3

75.4 ± 9.6

0.03^**

2 weeks

70.0 ± 8.2

0.27^*

72.7 ± 7.4

0.15^*

0.03^**

4 weeks

71.4 ± 7.5

0.30^*

74.3 ± 9.1

0.26^*

0.07^**

8 weeks

71.2 ± 6.6

0.99^*

73.7 ± 9.1

0.47^*

0.26^**

Pulse bpm

Day 0

67.0 ± 7.3

68.0 ± 6.0

0.35^**

2 weeks

65.5 ± 5.3

0.12^*

67.3 ± 6.0

0.38^*

0.14^**

4 weeks

66.4 ± 6.8

0.54^*

67.6 ± 6.5

0.63^*

0.36^**

8 weeks

66.6 ± 8.2

0.44^*

66.9 ± 7.3

0.80^*

0.65^**