Parameters | Empagliflozin (N = 751) | DPP-4 Inhibitors (N = 751) | Rate Ratio |
Incidence of DKA | |||
Patients with events in the period, n (%) | 1 (0.1) | 1 (0.1) |
|
Patients without event, n (%) | 750 (99.9) | 750 (99.9) |
|
Crude incidence rate | 0.001 | 0.001 | 1 |
(95% confidence interval) | 0 (0.007) | 0 (0.007) |
|
Treatment-adjusted incidence rate |
|
|
|
(crude per 1000 patient-years) | 1.380 | 1.407 | 0.981 |
(95% confidence interval) | (0.035, 7.690) | (0.036, 7.842) |
|
Incidence of volume depletion | |||
Patients with events in the period, n (%) | 6 (0.8) | 7 (0.9) |
|
Patients without event, n (%) | 745 (99.2) | 744 (99.1) |
|
Crude incidence rate | 0.008 | 0.009 | 0.889 |
(95% confidence interval) | (0.003, 0.017) | (0.004, 0.019) |
|
Treatment-adjusted incidence rate |
|
|
|
(crude per 1000 patient-years) | 8.282 | 9.852 | 0.841 |
(95% confidence interval) | (3.04, 18.03) | (3.96, 20.30) |
|