Parameters

Empagliflozin (N = 751)

DPP-4 Inhibitors (N = 751)

Rate Ratio

Incidence of DKA

Patients with events in the period, n (%)

1 (0.1)

1 (0.1)

Patients without event, n (%)

750 (99.9)

750 (99.9)

Crude incidence rate

0.001

0.001

1

(95% confidence interval)

0 (0.007)

0 (0.007)

Treatment-adjusted incidence rate

(crude per 1000 patient-years)

1.380

1.407

0.981

(95% confidence interval)

(0.035, 7.690)

(0.036, 7.842)

Incidence of volume depletion

Patients with events in the period, n (%)

6 (0.8)

7 (0.9)

Patients without event, n (%)

745 (99.2)

744 (99.1)

Crude incidence rate

0.008

0.009

0.889

(95% confidence interval)

(0.003, 0.017)

(0.004, 0.019)

Treatment-adjusted incidence rate

(crude per 1000 patient-years)

8.282

9.852

0.841

(95% confidence interval)

(3.04, 18.03)

(3.96, 20.30)