| Study | Number of patients (Man/Female) | Intervation | Duration (month) | Outcomes | ||
| Experimental | Control | Experimental | Control | |||
| Ju SB 2007 [19] | 46 (28/18) | 44 (26/18) | BBR 0.6/d + LM | LM | 12 | ①②③④⑥ |
| Zhang ZJ 2018 [20] | 50 (27/23) | 50 (32/18) | BBR 0.3 tid + LM | LM | 4 | ①⑥⑦ |
| Chang HY 2020 (1) [21] | 80 (45/35) | 80 (42/38) | BBR 30 mg tid | LM | 6 | ①②③④⑥⑦ |
| Chang HY 2020 (2) [21] | 80 (45/35) | 80 (41/39) | BBR 30 mg tid | Met 0.25 tid → 0.5 tid | 6 | ①②③④⑥⑦ |
| Zhang Z 2020 [22] | 24 (-/-) | 24 (-/-) | BBR 0.2 tid + LM | LM | 2 | ⑥ |
| Wang L 2020 (1) [23] | 35 (19/16) | 35 (19/16) | BBR 0.3 tid + LM | LM | 3 | ①②③④⑦ |
| Wang L 2020 (2) [23] | 34 (19/15) | 33 (18/15) | BBR 0.3 tid + LM | LM | 3 | ①②③④⑦ |
| Zhao JQ 2018 [24] | 32 (26/6) | 32 (24/8) | BBR 0.3 tid + LM | LM | 3 | ①②③⑥ |
| Chen YM 2017 [25] | 50 (31/19) | 50 (30/20) | BBR 0.5 tid | Met 0.25 tid | 6 | ①②⑥ |