| Class | Comment |
| Metformin | Not recommended in severe/critical patients; patients with gastrointestinal symptoms or lack of oxygen. |
| Secretagogue | Mild/moderate patients using glucocorticoid: · Short-acting agents can be used in early stage; · Middle/long-acting agents if FPG and/or PPG increased or in advanced stage. |
| α-glucosidase inhibitor | Can be used to control PPG. Not recommended in severe/critical patients; or in patients with gastrointestinal symptoms. |
| TZD | Can be used during the process of glucocorticoid treatment. Regime should be adjusted according to treatment effect. |
| DPP-4i | Not recommended |
| SGLT-2i | Not recommended for COVID-19 patients having stress reaction at different levels. |