JTT-751 (n = 35)

CaCO₃ (n = 35)

All participants

Baseline

24 months

Baseline

24 months

AoACS

4 (0 - 7)

5 (3 - 9)*

2 (0 - 5)

3 (2 - 5)*

Δ% AoACS

1 (0 - 3)

0 (0 - 3)

JTT-751 (n = 20)

CaCO₃ (n = 22)

Baseline AoACS ≤ 4

Baseline

24 months

Baseline

24 months

AoACS

0 (0 - 3)

3 (2 - 4)*

2 (0 - 2)

3 (0 - 4)*

Δ% AoACS

2 (0 - 3)

1 (0 - 3)

JTT-751 (n = 15)

Calcium Carbonate (n = 13)

Baseline AoACS > 4

Baseline

24 months

Baseline

24 months

AoACS

7 (6 - 10)

8 (6 - 11)

6 (5 - 6)

5 (5 - 9)

Δ% AoACS

1 (0 - 2)

0 (0-3)