Before switching to IBN

After switching to IBN

Friedman/

Wilcoxon^#

Before oral BP (T1)

After oral BP (T2)

6 months (T3)

12 months

Serum NTX (nmolBCE/L)

14.0 [13.3, 19.1]

18.0 [15.5, 19.7]*

13.3 [12.0, 15.9]^**

12.9 [11.0, 15.7]^***

< 0.0001

% change vs. T1

21.7 [3.0, 32.1]

-3.8 [-21.8, -0.2]^***

-10.3 [-23.6, -1.3]^***

0.0003

% change vs. T2

-27.3 [-32.5, -17.7]

-25.8 [-38.0, -9.0]

0.5760^#

% change vs. T3

-0.9 [-9.2, 1.9]

Serum BAP (μg/L)

10.3 [8.4, 11.5]

10.5 [9.5, 11.3]

9.1 [7.7, 9.8]^*,**

9.5 [8.1, 10.9]

0.0003

% change vs. T1

5.5 [-4.5, 17.3]

-10.5 [-18.8, -4.4]^***

-8.6 [-14.5, 0.7]

0.0003

% change vs. T2

-17.1 [-22.2, -14.8]

-14.2 [-19.3, -10.5]

0.0303^#

% change vs. T3

4.1 [0.8, 7.8]