Measurement

Liraglutide group

Dulaglutide group

Baseline

6-months

12-months

P value

Baseline

6-months

12-months

P value

BMI (kg/m²)

39.4 ± 6.4

38.3 ± 6.5

37.6 ± 6.7

<0.0005

38.8 ± 6.8

37.9 ± 6.5

37.2 ± 6.6

0.004

SBP (mmHg)

128.9 ± 13.1

125.6 ± 12.9

123.3 ± 13.5

0.147

127.4 ± 20.1

129.1 ± 13.2

125.1 ± 15.7

0.625

DBP (mmHg)

75.5 ± 8.1

76.6 ± 9

77.5 ± 8.4

0.522

74 ± 1.9

76.5 ± 1.6

73.1 ± 2.1

0.292

Pulse (bpm)

82.3 ± 10.6

85.7 ± 11.8

82.7 ± 11.4

0.332

86.5 ± 14

89.6 ± 14.1

87.9 ± 11.6

0.495

RPP

10629 ± 1487

10800 ± 1949

10278 ± 1860

0.396

11049 ± 2629

11507 ± 1866

11003 ± 2066

0.480

FPG (mmol/l)

11.3 ± 4

8.7 ± 3.5

7 ± 1.7

<0.001

15.4 ± 3.5

10.1 ± 5.3

9.5 ± 5.4

0.053

HbA1C %

8.55 ± 1.6

7.98 ± 1.6

7.18 ± 1.04

<0.001

8.84 ± 1.8

8.23 ± 1.5

7.5 ± 0.79

0.007

Serum Cr (mmol/l)

76.95 ± 23.8

73.62 ± 17.8

74.14 ± 21.0

0.425

79.75 ± 17.6

86.5 ± 20.4

85.75 ± 19.8

0.086

BUN (mmol/dl)

6.76 ± 1.8

6.86 ± 1.7

5.14 ± 1.6

0.019

8.5 ± 4.4

7.2 ± 2

5.4 ± 0.7

0.368

eGFR (ml/min/1.73m²)

125.3 ± 45.9

122 ± 40.2

120.4 ± 38.2

0.540

123.6 ± 60

105.5 ± 46.3

104.9 ± 47.3

0.008

ACR (mg/gm)

35.6 ± 57.5

-

42.8 ± 60

0.232

31.6 ± 52.6

-

33.2 ± 61

0.677

T-C (mmol/l)

4.38 ± 0.93

-

4.01 ± 0.74

0.241

3.7 ± 2.3

-

3.2 ± 1.3

0.558

LDL-C (mmol/l)

2.53 ± 0.88

-

2.37 ± 0.72

0.645

1.99 ± 1.82

-

1.57 ± 0.86

0.557

HDL-C (mmol/l)

1.28 ± 0.34

-

1.27 ± 0.37

0.916

1.21 ± 0.3

-

1.17 ± 0.24

0.373

TG (mmol/l)

1.6 ± 0.6

-

1.5 ± 0.5

0.499

1.3 ± 0.9

-

1.7 ± 1.1

0.293