Study (reference)

Comparators

Proportion of patients achieving < 7% of A1c atrial end

Riddle et al. 2003

NPH insulin

Insulin glargine

57%

58%

Meneghini et al. 2013

Insulin glargine

Insulin detemir

53%

38%

Fritsche et al. 2010

Basal bolus (glargine/glulisine)

Biphasic (NPH/RI or NPH/aspart)

48%

28%

Buse et al. 2009

Biphasic (Lispro Mix 75:25)

Insulin glargine

48%

40%

Liebl et al. 2009

Basal-bolus (detemir/aspart)

Biphasic (aspart 30:70)

60%

50%