Characteristic

n

Estradiol (pg/ml)

Sickle Cell

Healthy (Control)

% Reduction

Sickle Cell vs. Control^β

Mean ± SEM

Mean ± SEM

Test Statistics p-value

Age Group (years)

21 - 25

5

596.20 ± 54.65^a

960.32 ± 178.44

0.015*

26 - 30

49

369.34 ± 27.71^b

896.40 ± 60.51

<0.0001****

30+

6

308.52 ± 52.50^b

608.78 ± 135.86

0.066^ns

Trimester

1st Trimester (4 - 12 Wks)

20

246.74 ± 15.05^a

429.00 ± 30.06^a

42.48

<0.0001****

2nd Trimester (13 - 25 Wks)

20

416.73 ± 36.86^b

847.64 ± 34.27^b

50.84

<0.0001****

3rd Trimester (26 - 40 Wks)

20

630.49 ± 39.76^c

1342.25 ± 54.67^c

53.02

<0.0001****