Study

Year

Study types

Cases/controls

Age, (years)

Gender (male, %)

Follow-up period (years)

Study

Year

Arnold [12]

2009

Retrospective

23/107

53.7 ± 14.6*

56.2 ± 14^

69.6%*

57%^

6.8 ± 4.2

NFPA

6

Buchfelder [14]

2007

Retrospective

55/55

50.6 ± 9.7

NA

5

NFPA

7

Brignardello [13]

2015

Retrospective

26/23

NA

61.2%

11

Second neoplasms

6

Child [20]

2015

Prospective

8418/1268

45.5*

53.8^

52%*

59%^

4.8

3.5

Primary malignancies

7

Hartman [15]

2013

Prospective

1988/442

46 ± 15*

56%*

2.3

Intracranial tumor

Second neoplasms

7

Hatrick [16]

2002

Prospective

47/28

49*

52^

46.8%*

64.3%

3.6

Pituitary tumor

7

Mackenzie [17]

2011

Retrospective

69/68

33*

29^

54.5%*

48.2%^

14.5*

15^

Tumor recurrence

Second tumor

8

Olsson [18]

2009

Prospective

121/114

66.7 ± 11.2*

66.7 ± 11.0^

66%

13.6 ± 5.0*

13.4 ± 7.8^

Craniopharyngioma

8

Olsson [19]

2012

Prospective

56/70

46.6 ± 16.1*

45.7 ± 16.2^

57%*

49%^

14.5*

15^

Tumor recurrence

Second tumor

8

Olsson [21]

2017

Prospective

207/219

56.3*

65.2^

70%*

59%^

12.2*

8.2^

Malignant tumors

8