Figure 2

miR-217

decrease

SIRT1

increase

miR217 ―SIRT1 ―EMT

Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway

miR217 is highly pancreas specific and it is shown to involve in progression of CP to pancreatic cancer

25172416

Figure 2,

miR-191

decrease

IL1

increase

miR191 ―IL1

hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy

No proposed role of miR191, however elevation of proinflammatory cytokines (IL1a, IL1b) were reported in CP

20924108, 22487478

Figure 2

miR-181

decrease

SMAD

increase

miR-181 ―TGFB ―SMAD

miR-181a can affect the phosphorylation of Smad2 through activation of TGF-β signaling

Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice.

22714950, 15502860

Figure 2

miR-200b

decrease

ZEB1

increase

miR-200b ―ZEB1

Participation of miR-200 in pulmonary fibrosis

miR-200 family were implicated in progression of fibrosis

25172416, 22189082