Figure 2 | miR-217 | decrease | SIRT1 | increase | miR217 ―SIRT1 ―EMT | Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway | miR217 is highly pancreas specific and it is shown to involve in progression of CP to pancreatic cancer | 25172416 |
Figure 2, | miR-191 | decrease | IL1 | increase | miR191 ―IL1 | hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy | No proposed role of miR191, however elevation of proinflammatory cytokines (IL1a, IL1b) were reported in CP | 20924108, 22487478 |
Figure 2 | miR-181 | decrease | SMAD | increase | miR-181 ―TGFB ―SMAD | miR-181a can affect the phosphorylation of Smad2 through activation of TGF-β signaling | Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. | 22714950, 15502860 |
Figure 2 | miR-200b | decrease | ZEB1 | increase | miR-200b ―ZEB1 | Participation of miR-200 in pulmonary fibrosis | miR-200 family were implicated in progression of fibrosis | 25172416, 22189082 |