IPA Network (Figure)	miRNA		miRNA target		Regulatory feedback loop	Confirmed biological functions	Proposed role in CP	Ref. nos.
IPA Network (Figure)	Gene	FC	mRNA	FC	Regulatory feedback loop	Confirmed biological functions	Proposed role in CP	Ref. nos.
Figure 2	miR130b	decrease	MafB	decrease	miR-130b ―MafB	MicroRNA fingerprints during human megakaryocytopoiesis.	Maf family transfription factors may be involved in beta cell dysfunction	23863625
Figure 2	miR-27b	decrease	FoxO1	increase	miR-27b ―FoxO1	Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.	FoxO1 gain of function in pancreas causes glucose intolerance, polycystic pancreas, and islet hyper vascularization.	19574223, 22384192
Figure 2	miR-29 family	decrease	IFN G	increase	miR-29 ―IFN g	miR29 controls innate and adaptive immune responses to intracellular bacterial infection bytargeting interferon-γ.	Interferon γ and glycemic status in diabetes associated with chronic pancreatitis and its role in fibrogenesis	21785411, 22487478, 20971881
Figure 2	miR375	decrease	JAK2	Not known	miR375 ―JAK2	miR-375 may function as a tumor suppressor to regulate gastric cancer cell proliferation potentially by targeting the JAK2 oncogene, implicating a role of miR-375 in the pathogenesis of gastric cancer	JAK2 mediated pathways were shown to stimulate replication and survival of β-cells	20548334, 22045263