Age at cardiac surgery

Reduced creatinine clearance (GFR < 45 mL/min)

High central venous pressure (≥15 mmHg)

Severe tricuspidal regurgitation associated to low TAPSE (<16 mm)

Depressed ejection fraction (<50%)

Presence of esophagogastric varices (F3)

Conjugated hyperbilirubinemia (>2.5 mg/dL)

Low serum Cholinesterasis (CHE < 2000 UI/L)

Hypoalbuminemia (<3 g/dL)

Basal leucopenia (WBC < 2000 µL)

INR correction unresponsive to vitamin K administration

Low ICG-PDR value (<8.2%/min)

Thrombocytopenia (Platelet < 100.000 µL)