| Parameters/metabolic disorders | Naive patient n (%) | Types of therapy | ||||
| Monotherapy n (%) | Bitherapy n (%) | Tritherapy n (%) | P-vaue | |||
| Natremia | Normal natremia | 47 (66.2%) | 59 (69.4%) | 45 (67.2%) | 13 (61.9%) | 0.611 |
| Hyponatremia | 3 (4.1%) | 3 (3.5%) | 0 (0%) | 0 (0%) | ||
| Hypernatremia | 21 (29.6%) | 23 (27.1%) | 22 (32.8%) | 8 (38.1%) | ||
| Chloremia | Normal chloremia | 61 (85.9%) | 65 (76.5%) | 49 (73.1%) | 15 (71.4%) | 0.13 |
| Hypochloremia | 5 (6.8%) | 14 (16.5%) | 7 (10.4%) | 0 (0%) | ||
| Hyperchloremia | 5 (6.8%) | 6 (7.1%) | 11 (16.4%) | 6 (28.6%) | ||
| Kalemia | Normal kaliemia | 43 (60.6%) | 73 (85.9%) | 50 (74.6%) | 21 (100%) | 0.000 |
| Hypokaliemia | 5 (6.8%) | 4 (4.7%) | 7 (10.4%) | 0 (0%) | ||
| Hyperkaliemia | 23 (31.5%) | 8 (9.4%) | 10 (14.9%) | 0 (0%) | ||
| Total Cholesterol | Normal cholesterolemia | 68 (95.7%) | 80 (94.1%) | 64 (95.5%) | 21 (100%) | 0.711 |
| Hyper cholesterolemia | 3 (4.1%) | 5 (5.9%) | 3 (4.5%) | 0 (0%) | ||
| HDL-cholesterol | Normal HDL-cholesterolemia | 17 (23.9%) | 64 (75.3%) | 57 (85.1%) | 13 (61.9%) | 0.000 |
| Hypo HDL-cholesterolemia | 54 (76.1%) | 21 (25.0%) | 10 (14.9%) | 8 (38.1%) | ||
| Triglycerides | Normal triglyceridemia | 55 (77.5%) | 69 (81.2%) | 56 (83.6%) | 14 (66.7%) | 0.371 |
| Hypertriglyceridemia | 16 (22.5%) | 16 (18.8%) | 11 (16.4%) | 7 (33.3%) | ||
| LDL-Cholesterol | Normal LDL-cholesterolemia | 68 (95.8%) | 73 (85.9%) | 94.0% (63) | 21 (100%) | 0.44 |
| Hyper LDL-cholesterolemia | 3 (4.1%) | 12 (14.2%) | 4 (6%) | 0 (0%) | ||
| Glycemia | Normoglycemia | 37 (52.1%) | 42 (49.4%) | 37.3% (25) | 12 (57.1%) | 0.003 |
| Hypoglycemia | 5 (6.8%) | 13 (15.3%) | 12 (17.9%) | 8 (38.1%) | ||
| Hyperglycemia | 29 (40.8%) | 30 (35.7%) | 30 (44.8%) | 1 (4.8%) | ||
| ASAT | Normal ASAT | 70 (98.6%) | 74 (87.1%) | 61 (91.0%) | 21 (100%) | 0.007 |
| High ASAT | 1 (1.4%) | 11 (12.9%) | 6 (9.0%) | 0 (0%) | ||
| ALAT | Normal ALAT | 71 (100%) | 83 (97.6%) | 66 (98.5%) | 21 (100%) | 0.559 |
| High ALAT | 0 (0%) | 2 (2.4%) | 1 (1.5%) | 0 (0%) | ||
| Creatininemia | Normal creatininemia | 36 (50.7%) | 58 (68.2%) | 39 (58.2%) | 13 (61.9%) | 0.167 |
| Hypercreatininemia | 35 (49.3%) | 27 (31.8%) | 28 (41.8%) | 8 (38.1%) | ||
| Hematuria | Hematuria (−) | 66 (92.9%) | 81 (95.3%) | 58 (86.6%) | 21 (100%) | 0.066 |
| Hematuria (+) | 5 (6.8%) | 4 (4.7%) | 9 (13.4%) | 0 (0%) | ||
| Proteinuria | Proteinuria (−) | 35 (49.3%) | 55 (64.7%) | 44 (65.7%) | 17 (81.0%) | 0.034 |
| Proteinuria (+) | 36 (50.7%) | 30 (35.3%) | 23 (34.3%) | 4 (19.0%) | ||
| Glycosuria | Glycosuria (−) | 63 (88.7%) | 76 (89.4%) | 56 (83.6%) | 21 (100%) | 0.084 |
| Glycosuria (+) | 8 (11.0%) | 9 (10.6%) | 11 (16.4%) | 0 (0%) | ||