End tidal isoflurane concentration

(Anesthetic requirements)

Bispectral index

State entropy

Significant disagreement between BIS and SE by more than 15

Disagreement (yes/total; %)

ET-iso

P value

BIS

P value

SE

P value

|BIS-SE| > 15

P value

MELD

<20 (n = 2094)

≥20 (n = 801)

0.8 [0.6 - 0.9]

0.4 [0.3 - 0.5]*

<0.001

49.0 [44.0 - 56.0]

44.0 [42.0 - 49.0]*

<0.001

47.0 [40.0 - 55.0]

32.0 [27.0 - 43.0]*

<0.001

117/2094 (5.6%)

203/801 (25.3%)*

<0.001

Etiology

Alcoholic (n = 493)

Hepatitis viral (n = 2193)

Miscellaneous (n = 209)

0.4 [0.2 - 0.6]*^†

0.7 [0.5 - 0.8]^†

1.0 [0.9 - 1.1]

<0.001

<0.001

45.0 [42.0 - 54.0]*^†

48.0 [44.0 - 55.0]^†

50.0 [44.0 - 58.0]

<0.001

0.001

32.0 [27.0 - 48.0]*^†

45.0 [37.0 - 53.0]

44.0 [38.0 - 57.0]

<0.001

0.073

131/493 (26.6%)

169/2193 (7.7%)

20/209 (9.6%)

<0.001

LT stages

Preanhepatic (n = 216)

Anhepatic (n = 906)

Postreperfusion (n = 1773)

0.7 [0.5 - 0.8]

0.6 [0.5 - 0.8]*

0.7 [0.5 - 0.9]

0.047

48.0 [44.0 - 54.5]

47.0 [42.0 - 54.0]^†

48.0 [44.0 - 55.0]

<0.001

45.0 [39.0 - 51.5]

44.0 [35.0 - 52.0]

44.0 [34.0 - 53.0]

0.144

12/216 (5.6%)

67/906 (7.4%)

241/1773 (13.6%)

<0.001