| Type of defect | Lipoprotein increased | Pathological effects |
| Familial hypercholestemia | LDL | Defective or lack of LDL receptors |
| Familial defective apoB | LDL | apoB with LDL receptor binding |
| Familial combined hyperlipoproteinemia | VLDL and LDL | Overproduction of apoB containing lipoproteins |
| Dysbetalipoproteinemia | Remnants | Abnormal apoE |
| Hypertriglyceridemia | Moderate-VLDL, Severe VLDL and Chylomicrons | Over production of triglyceride; defective catabolism |
| Genetic lipoprotein lipase or apo CII deficiency | Chylomicrons | Defective catabolism |