Variable | Control group (n)31 | Nicorandil group (n)31 | p value | |
Post-op uses of inotropic drugs | yes | 18 (59%) | 9 (29%) | 0.018* |
No | 13 (41%) | 22 (71%) | ||
Overall number of inotropic drugs | 1.48 ± 1.07 | 0.66 ± 0.73 | 0.048* | |
Post-operative R-wave amplitude reduction in V5 (4 h) mm | 4.6 ± 0.85 | 3.63 ± 0.89 | 0.011* | |
post-op LVEF% | 56.48 ± 3.66 | 62.22 ± 3.55 | 0.048* | |
Post-operative CKMB | 4 hours | 51.76 ± 3.87 | 38.67 ± 3.44 | 0.031* |
12 hours | 43.08 ± 2.43 | 34.75 ± 2.33 | 0.001* | |
48 hours | 14.05 ± 2.66 | 13.05 ± 3.55 | 0.816 | |
Post-operative Troponin I | 4 hours | 1.36 ± 0.18 | 1.12 ± 0.16 | 0.017* |
12 hours | 1.54 ± 0.31 | 1.18 ± 0.22 | 0.006* | |
48 hours | 0.54 ± 0.44 | 0.52 ± 0.45 | 0.741 | |
Post-operative tumor necrosis factor alpha (TNF-α) | 4 hours | 20.3 ± 2.44 | 15.17 ± 1.56 | 0.001* |
12 hours | 16.36 ± 2.37 | 13.17 ± 1.55 | 0.081* | |
48 hours | 12.33 ± 1.44 | 12.1 ± 1.25 | 0.649 | |
Post-operative interleukin 6 (IL-6) | 4 hours | 36.71 ± 2.99 | 27.06 ± 3.4 | 0.021* |
12 hours | 29.84 ± 5.66 | 23.18 ± 3.46 | 0.004* | |
48 hours | 22.66 ± 1.99 | 21.77 ± 2.36 | 0.162 | |
Intensive care unit stay | 2.66 ± 0.55 | 2.49 ± 0.33 | 0.588 | |
Length of post-operative hospital stay | 11.10 ± 1.35 | 10.85 ± 1.20 | 0.964 |