| Clinical characteristics | No. of patients | ARID1A | ATM | NF2 | PTEN | STAG2 | ||||||||||
| Mut | χ2 | p | Mut | χ2 | p | Mut | χ2 | p | Mut | χ2 | p | Mut | χ2 | p | ||
| Total | 262 |
| ||||||||||||||
| Sex |
|
| ||||||||||||||
| Male | 169 | 15 | 0.142 | 0.706 | 11 | 0.712 | 0.399 | 7 | 1.011 | 0.315 | 5 | 0.000 | 1.000 | 3 | 0.000 | 1.000 |
| Female | 93 | 7 |
|
| 3 |
|
| 1 |
|
| 3 |
|
| 2 |
|
|
| Age |
| |||||||||||||||
| <60 | 134 | 14 | 1.500 | 0.221 | 7 | 0.008 | 0.930 | 5 | 0.086 | 0.769 | 2 | 1.307 | 0.253 | 4 | 0.725 | 0.394 |
| ≥60 | 128 | 8 |
|
| 7 |
|
| 3 |
|
| 6 |
|
| 1 |
|
|
| Race |
| |||||||||||||||
| Asian | 156 | 15 | 0.744 | 0.388 | 9 | 0.138 | 0.710 | 5 | 0.000 | 1.000 | 5 | 0.000 | 1.000 | 3 | 0.000 | 1.000 |
| non-Asian | 106 | 7 |
|
| 5 |
|
| 3 |
|
| 3 |
|
| 2 |
|
|
| Pathological typing |
| |||||||||||||||
| HCC | 225 | 19 | 0.270 | 1.000 | 13 | 0.584 | 0.747 | 7 | 0.921 | 1.000 | 6 | 2.200 | 0.347 | 3 | 4.294 | 0.179 |
| ICC | 34 | 3 |
|
| 1 |
|
| 1 |
|
| 2 |
|
| 2 |
|
|
| cHCC-ICC | 3 | 0 |
|
| 0 |
|
| 0 |
|
| 0 |
|
| 0 |
|
|
| Primary site |
| |||||||||||||||
| Liver | 228 | 19 | 0.000 | 1.000 | 13 | 0.067 | 0.796 | 1 | 0.000 | 1.000 | 6 | 0.244 | 0.622 | 3 | 1.308 | 0.253 |
| Intrahepatic bile duct | 34 | 3 |
|
| 1 |
|
| 1 |
|
| 2 |
|
| 2 |
|
|
| Treatment type |
| |||||||||||||||
| Pharmaceutical therapy, NOS | 132 | 11 | 0.001 | 0.970 | 7 | 0.001 | 0.977 | 5 | 0.114 | 0.736 | 4 | 0.000 | 1.000 | 3 | 0.000 | 1.000 |
| Radiation therapy, NOS | 130 | 11 |
|
| 7 |
|
| 3 |
|
| 4 |
|
| 2 |
|
|
| T stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| T1 - T2 | 183 | 13 | 1.319 | 0.251 | 8 | 0.586 | 0.444 | 3 | 0.669 | 0.102 | 5 | 0.005 | 0.945 | 3 | 0.000 | 1.000 |
| T3 - T4 | 79 | 9 |
|
| 6 |
|
| 5 |
|
| 3 |
|
| 2 |
|
|
| M stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| M0 | 248 | 19 | 1.721 | 0.190 | 12 | 0.843 | 0.358 | 7 | 0.013 | 0.908 | 8 | 0.000 | 1.000 | 4 | 0.219 | 0.640 |
| M1 | 14 | 3 |
|
| 2 |
|
| 1 |
|
| 0 |
|
| 1 |
|
|
| N stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| N0 | 252 | 21 | 0.000 | 1.000 | 13 | 0.000 | 1.000 | 8 | 0.000 | 1.000 | 7 | 0.133 | 0.715 | 5 | 0.000 | 1.000 |
| N1 | 10 | 1 |
|
| 1 |
|
| 0 |
|
| 1 |
|
| 0 |
|
|
| Stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| I - II | 177 | 13 | 0.785 | 0.375 | 8 | 0.316 | 0.574 | 3 | 2.134 | 0.144 | 5 | 0.000 | 1.000 | 3 | 0.000 | 1.000 |
| III - IV | 85 | 9 |
|
| 6 |
|
| 5 |
|
| 3 |
|
| 2 |
|
|