VPZ

PPI

LPZ

RPZ

p value

A

B

c

d

A vs. B

A vs. c

A vs. d

c vs. d

No. of patients enrolled

1286

2832

2393

439

Completed the therapy

1123

2381

2000

381

Age (Years)

57.9 ± 11.3

60.1 ± 10.7

60.0 ± 10.7

61.0 ± 10.8

<.0001

<.0001

<.0001

0.083

Range

24 - 86

26 - 88

26 - 88

30 - 84

Gender

0.613

0.994

0.050

0.038

Male

673

1458

1252

206

Female

613

1374

1141

233

BMI (kg/m²)

22.8 ± 3.1

22.6 ± 3.1

22.6 ± 3.1

22.5 ± 3.1

0.120

0.203

0.081

0.305

Range

14.7 - 42.0

14.3 - 46.

14.3 - 46.0

15.4 - 36.7

Endoscopic findings

<.0001

<.0001

0.038

0.524

No abnormality

38

23

19

4

Duodenal ulcer

10

56

48

8

Atrophic gastritis

1199

2586

2181

405

Gastric ulcer

38

165

145

20

After ER for GC

1

2

0

2

Smoking (yes)

189

348

303

45

0.033

0.084

0.019

0.157

Drinking (yes)

624

1336

1140

196

0.422

0.609

0.160

0.248

Successful eradication*

1026

1878

1586

292

ITT analysis %

(95%CI)

79.8

(77.5 - 81.9)

66.3

(64.6 - 68.0)

66.3

(64.4 - 68.1)

66.5

(62.0 - 70.8)

<.0001

<.0001

<.0001

0.874

PP analysis %

(95%CI)

91.4

(89.6 - 92.9)

78.9

(77.2 - 80.5)

79.3

(77.5 - 81.0)

76.6

(72.1 - 80.6)

<.0001

<.0001

<.0001

0.244

Adverse events

51

104

78

26

0.647

0.267

0.087

0.006