Group

Early cases

Late cases

p-value

Time period:

1993-1996

2006-2011

# Cancers

106

69

MSS

91 (85.8)

58 (84.1)

MSI-high

15 (14.2)

11 (15.9)

0.40

Methylated

14 (93.3%)

10 (90.9%)

Methylated and BRAF* mutated

9 (64.3%)

6 (60%)

Methylated and BRAF wild

5 (35.7%)

4 (40%)

Unmethylated and BRAF wild

1 (6.7%)

1 (9.1%)