| |||||||
CPD | R1 | R2 | R3 | R4 | CC50 (μM)c | (IC50, μM) | |
H3N2a | H1N1b | ||||||
3 |
|
|
|
| >100 | 1.93 | 1.15 |
10 | H | H | H | H | >100 | 19.32 | 19.52 |
11 | Me | H | H | H | >100 | 6.24 | 5.20 |
12 | H | Me | H | H | >100 | 14.25 | 14.96 |
13 | H | H | Me | H | >100 | 9.74 | 5.87 |
14 | Cl | H | H | H | >100 | 9.0 | 4.93 |
15 | H | Cl | H | H | >100 | 18.71 | 11.14 |
16 | H | H | Cl | H | >100 | 5.34 | 7.66 |
17 | Br | H | H | H | >100 | 6.59 | 4.24 |
18 | H | Br | H | H | >100 | 13 | 11.28 |
19 | H | H | Br | H | >100 | 8.53 | 7.85 |
20 | NO2 | H | H | H | >100 | 10.23 | 6.2 |
21 | H | NO2 | H | H | >100 | 37.45 | 27.19 |
22 | H | H | NO2 | H | 16.41 | 3.45 | 3.01 |
23 | OH | H | H | H | >100 | 12.4 | 4.72 |
24 | NH2 | H | H | H | >100 | 16.79 | 12.84 |
25 | Et | H | H | H | >100 | 5.47 | 9.69 |
26 | Cyclopropyl | H | H | H | >100 | 8.21 | 11.55 |
27 | OMe | H | H | H | >100 | 6.45 | 6.16 |
28 | H | H | CN | H | 16.12 | 3.86 | 3.5 |
29 | H | H | CO2Me | H | >100 | 48.12 | 66.03 |
30 | Me | H | H | NH2 | 27.01 | 3.38 | 0.65 |
31 | Me | H | H | NO2 | >100 | 4.5 | 3.28 |
32 | Me | H | H | Br | >100 | 2.61 | 1.07 |
33 | Me | H | H | Cl | 17.82 | 1.78 | 0.52 |
34 | Me | H | H | Me | >100 | 13.41 | 4.88 |
35 | Me | H | NO2 | H | >100 | 3.9 | 2.11 |
36 | Me | H | Br | H | 9.19 | 2.66 | 2.9 |
37 | Br | H | NO2 | H | 53.77 | 1.88 | 1.23 |
38 | F | H | Br | H | >100 | 9.08 | 5.33 |
39 | Me | H | CN | Cl | 1.53 | 0.46 | 0.27 |