Drug | Vaughan Williams | Indication | Onset of action | Half life | Protein binding and metabolism | Route of elimination |
Dronedarone | All four classes of Vaughan Williams | To decrease the chances of hospitalization in case of sudden/continual AF/AFL with current episode of AF/AFL & related CV risk factors [17] | 4 - 8 h | 13 - 19 h | >98% by CYP3A and CYP2D6 [23] | ~renal (6%) and feces (84%) [24] |
Amiodarone | All I - IV classes, but predominantly Class III | Paroxysmal supra-ventricular tachycardia (paroxysmal SVT); Recurrent ventricular fibrillation; Supra-ventricular arrhythmias; Unstable ventricular tachycardia; Recurrent supra-ventricular tachycardia; Management of acute AF and long term treatment to prevent recurrence of AF [22] | Few days to weeks (1 - 3) | 40 - 55 days | >96%, by CYP3A4 and CYP2C8 [25] | Metabolized by liver & biliary excretion [26] |