| Mean ± S.D. (Percent edema inhibition) | Analgesic activity | ||||||||
Comp. No. | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h | Potency | No. of writhing movements | Percent inhibition | Potency |
33a | 0.03 ± 0.02 (3.24) | 0.07 ± 0.04 (11) | 0.17 ± 0.03a (23.51) | 0.23 ± 0.02 (43) | 0.16 ± 0.06 (44.61) | 0.17 ± 0.06 (45.71) | 0.51 | 22 | 60 | 0.71 |
33b | 0.23 ± 0.06 (7.42) | 0.22 ± 0.03 (15.41) | 0.12 ± 0.04a (41) | 0.12 ± 0.05 (0) | 0.18 ± 0.03 (48.21) | 0.19 ± 0.06 (59.42) | 0.67 | 19 | 65.45 | 0.78 |
34a | 0.34 ± 0.03 (7.31) | 0.37 ± 0.01 (17.42) | 0.17 ± 0.03 (33.76) | 0.33 ± 0.06 (0) | 0.16 ± 0.08 (68.41) | 0.17 ± 0.05 (75.30) | 0.85 | 15 | 72.72 | 0.86 |
34b | 0.24 ± 0.05 (11.42) | 0.14 ± 0.03 (0) | 0.28 ± 0.05 (42.87) | 0.15 ± 0.09 (59.42) | 0.21 ± 0.03 (0) | 0.03 ± 0.03 (77) | 0.87 | 18 | 67.27 | 0.80 |
35a | 0.36 ± 0.03 (10) | 0.35 ± 0.03 (1.75) | 0.46 ± 0.08 (18) | 0.38 ± 0.05 (23.51) | 0.44 ± 0.05 (25.61) | 0.26 ± 0.07 (31.78) | 0.36 | 60 | --- | --- |
35b | 0.14 ± 0.05 (7.31) | 0.34 ± 0.06 (4.67) | 0.27 ± 0.03 (21.45) | 0.34 ± 0.04 (0) | 0.25 ± 0.08 (33.21) | 0.26 ± 0.05a,b (36) | 0.41 | 55 | --- | --- |
36a | 0.24 ± 0.01 (0) | 0.22 ± 0.02 (8.53) | 0.23 ± 0.06 (22.31) | 0.26 ± 0.04 (31.54) | 0.23 ± 0.03 (39.52) | 0.45 ± 0.06 (43.46) | 0.49 | 37 | 32.72 | 0.39 |
36b | 0.27 ± 0.04 (6.80) | 0.24 ± 0.03 (13.45) | 0.43 ± 0.08 (29.45) | 0.25 ± 0.03 (35) | 0.22 ± 0.06 (43.52) | 0.46 ± 0.07 (59.42) | 0.67 | 32 | 41.81 | 0.49 |
37a | 0.21 ± 0.05 (0) | 0.38 ± 0.04 (10.54) | 0.17 ± 0.03 (21.56) | 0.30 ± 0.02 (33.76) | 0.29 ± 0.03 (44) | 0.25 ± 0.03 (53.67) | 0.60 | 44 | 20 | 0.23 |
37b | 0.25 ± 0.04 (6.31) | 0.25 ± 0.05 (18.65) | 0.26 ± 0.08 (27) | 0.16 ± 0.08 (31.43) | 0.22 ± 0.09 (39.54) | 0.24 ± 0.06 (55) | 0.62 | 37 | 32.72 | 0.39 |
38a | 0.23 ± 0.04 (7.65) | 0.23 ± 0.06 (21.56) | 0.54 ± 0.05 (37.78) | 0.26 ± 0.02 (57.62) | 0.12 ± 0.09 (73.24) | 0.22 ± 0.09 (88) | 0.99 | 17 | 69.09 | 0.82 |
38b | 0.43 ± 0.02 (10.43) | 0.25 ± 0.05 (25.64) | 0.25 ± 0.03 (0) | 0.28 ± 0.04 (50.42) | 0.25 ± 0.09 (77.34) | 0.49 ± 0.10a,b (92.17) | 1.04 | 12 | 78.81 | 0.94 |
39a | 0.22 ± 0.04 (0) | 0.28 ± 0.03 (17.35) | 0.23 ± 0.01 (23) | 0.25 ± 0.03 (34.90) | 0.28 ± 0.01 (0) | 0.47 ± 0.07 (50) | 0.56 | 39 | 29.09 | 0.34 |
39b | 0.24 ± 0.02 (5.90) | 0.21 ± 0.06 (11) | 0.46 ± 0.08 (19.31) | 0.21 ± 0.07 (39) | 0.29 ± 0.05 (43.86) | 0.47 ± 0.08 (58.31) | 0.66 | 33 | 40 | 0.47 |
40a | 0.28 ± 0.03 (0) | 0.14 ± 0.04 (21.43) | 0.43 ± 0.07 (37.30) | 0.50 ± 0.05 (49) | 0.17 ± 0.08 (72) | 0.60 ± 0.04 (90) | 1.01 | 18 | 67.27 | 0.80 |
40b | 0.32 ± 0.04 (10.32) | 0.44 ± 0.10 (37.32) | 0.33 ± 0.03 (0) | 0.27 ± 0.02 (41.03) | 0.24 ± 0.04 (53.02) | 0.12 ± 0.03 (86.68) | 0.98 | 13 | 76.36 | 0.91 |