| Mean ± S.D. (Percent edema inhibition) | Analgesic activity | ||||||||
Comp. No. | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h | Potency | No. of writhing movements | Percent inhibition | Potency |
24a | 0.11 ± 0.04 (4.46) | 0.23 ± 0.03 (27.35) | 0.27 ± 0.06 (33.19) | 0.31 ± 0.02 (44.12) | 0.24 ± 0.07 (67.13) | 0.42 ± 0.06 (79.47) | 0.89 | 36 | 34.54 | 0.41 |
24b | 0.25 ± 0.04 (16.32) | 0.45 ± 0.05 (31.40) | 0.58 ± 0.07 (22.38) | 0.21 ± 0.05 (45.77) | 0.21 ± 0.06 (65.09) | 0.37 ± 0.05 (88.02) | 0.99 | 29 | 47.27 | 0.56 |
25a | 0.20 ± 0.01 (9.03) | 0.42 ± 0.05 (12.57) | 0.35 ± 0.05 (23.52) | 0.22 ± 0.07 (0) | 0.25 ± 0.04 (31.47) | 0.21 ± 0.03 (51.38) | 0.58 | 23 | 58.81 | 0.69 |
25b | 0.18 ± 0.04 (13.40) | 0.11 ± 0.02 (10.9) | 0.36 ± 0.02 (19.83) | 0.42 ± 0.10 (35.30) | 0.22 ± 0.05 (43.06) | 0.22 ± 0.07 (60.26) | 0.68 | 20 | 63.63 | 0.76 |
26a | 0.26 ± 0.03 (7.41) | 0.14 ± 0.05 (13.45) | 0.47 ± 0.06 (27.30) | 0.46 ± 0.02 (47.44) | 0.12 ± 0.02 (51.45) | 0.53 ± 0.06 (66.42) | 0.75 | 12 | 78.81 | 0.94 |
26b | 0.36 ± 0.03 (11.15) | 0.46 ± 0.02 (21.74) | 0.31 ± 0.04 (38.61) | 0.23 ± 0.02 (41.03) | 0.22 ± 0.04 (53.02) | 0.12 ± 0.04 (71.68) | 0.81 | 10 | 81.81 | 0.97 |
27a | 0.24 ± 0.02 (1.37) | 0.46 ± 0.07 (5.49) | 0.31 ± 0.02 (27.63) | 0.22 ± 0.02 (32.10) | 0.22 ± 0.05 (21.08) | 0.43 ± 0.01 (37.35) | 0.42 | 43 | 21.81 | 0.26 |
27b | 0.15 ± 0.05 (7.31) | 0.45 ± 0.01 (14.52) | 0.34 ± 0.02 (31.82) | 0.35 ± 0.04 (26.41) | 0.28 ± 0.03a,b (33.50) | 0.22 ± 0.02a (41.95) | 0.47 | 36 | 34.54 | 0.41 |
28a | 0.15 ± 0.03 (0) | 0.46 ± 0.01 (15.30) | 0.22 ± 0.02 (26.84) | 0.36 ± 0.02 (32.45) | 0.12 ± 0.05a,b (43.05) | 0.22 ± 0.04a (59.31) | 0.67 | 20 | 63.63 | 0.76 |
28b | 0.23 ± 0.03 (0) | 0.21 ± 0.08 (6.41) | 0.15 ± 0.03 (29.30) | 0.21 ± 0.02 (37.05) | 0.40 ± 0.01 (51.56) | 0.13 ± 0.07 (65.47) | 0.74 | 18 | 67.27 | 0.80 |
29a | 0.12 ± 0.02 (0) | 0.24 ± 0.05 (2.51) | 0.34 ± 0.02 (11.53) | 0.39 ± 0.02 (26) | 0.65 ± 0.03 (33.96) | 0.35 ± 0.03 (41.32) | 0.47 | 56 | --- | --- |
29b | 0.35 ± 0.02 (3.21) | 0.27 ± 0.02 (7.31) | 0.25 ± 0.06 (0) | 0.16 ± 0.02a,b (22.41) | 0.14 ± 0.07a,b (40) | 0.21 ± 0.04a,b (52.67) | 0.59 | 54 | --- | --- |
30a | 0.27 ± 0.01 (5.42) | 0.07 ± 0.01a (10.42) | 0.32 ± 0.03 (21.36) | 0.14 ± 0.06 (33.12) | 0.35 ± 0.08 (41.44) | 0.14 ± 0.05a (44) | 0.49 | 25 | 54.54 | 0.65 |
30b | 0.24 ± 0.03 (0) | 0.33 ± 0.03 (12.53) | 0.45 ± 0.02 (23.64) | 0.08 ± 0.02a (41.26) | 0.32 ± 0.08 (32.36) | 0.76 ± 0.03 (56.31) | 0.63 | 20 | 63.63 | 0.76 |
31a | 0.26 ± 0.03 (16.41) | 0.32 ± 0.04 (22.64) | 0.44 ± 0.07 (57.46) | 0.45 ± 0.05 (62) | 0.55 ± 0.07 (75.26) | 0.23 ± 0.05 (93.04) | 1.04 | 6 | 89.09 | 1.06 |
31b | 0.14 ± 0.05 (20.89) | 0.22 ± 0.07 (32.38) | 0.31 ± 0.02 (47.09) | 0.28 ± 0.04 (67.42) | 0.23 ± 0.06 (77) | 0.23 ± 0.05a,b (93.86) | 1.05 | 4 | 92.72 | 1.10 |
32a | 0.23 ± 0.03 (7.31) | 0.24 ± 0.037 (16.42) | 0.24 ± 0.03 (0) | 0.24 ± 0.04 (43.39) | 0.25 ± 0.07 (61.47) | 0.46 ± 0.06 (80) | 0.90 | 18 | 67.27 | 0.80 |
32b | 0.27 ± 0.03 (6.27) | 0.23 ± 0.02 (24.23) | 0.37 ± 0.05 (37.42) | 0.27 ± 0.03 (48.58) | 0.22 ± 0.04 (73.63) | 0.36 ± 0.09 (82.41) | 0.93 | 15 | 72.72 | 0.86 |