Mean ± S.D. (Percent edema inhibition)

Analgesic activity

Comp.

No.

1 h

2 h

3 h

4 h

5 h

6 h

Potency

No. of writhing movements

Percent inhibition

Potency

Control

0.23 ± 0.03

(----)

0.26 ± 0.05

(-----)

0.45 ± 0.01

(-----)

0.54 ± 0.08

(-----)

0.63 ± 0.04

(-----)

0.78 ± 0.12

(-----)

----

55

---

---

Indocin

0.22 ± 0.03

(11.73)

0.14 ± 0.03

(20.50)

0.21 ± 0.02

(44.12)

0.23 ± 0.04

(52.71)

0.22 ± 0.08

(69.5)

0.05 ± 0.02

(88.70)

1

9

83.63

1

4a

0.21 ± 0.03

(0.71)

0.25 ± 0.04

(4.23)

0.37 ± 0.03

(32.84)

0.5 ± 0.002

(21.06)

0.35 ± 0.06

(37)

0.32 ± 0.03

(50)

0.56

23

58.18

0.69

4b

0.34 ± 0.02

(6.31)

0.35 ± 0.03

(22.12)

0.36 ± 0.07

(37.20)

0.24 ± 0.02^a,b

(55.50)

0.16 ± 0.08^a,b

(73.5)

0.13 ± 0.03^a

(61.21)

0.69

15

72.72

0.86

4c

0.22 ± 0.03

(5.60)

0.26 ± 0.02

(13.21)

0.18 ± 0.02

(38.21)

0.33 ± 0.03

(43.10)

0.17 ± 0.04^a

(70.4)

0.13 ± 0.004^a

(74.16)

0.83

10

81.81

0.97

4d

0.21 ± 0.02

(8.81)

0.10 ± 0.02

(43.16)

0.22 ± 0.09

(56.32)

0.14 ± 0.01^a

(66)

0.22 ± 0.02

(72.4)

0.07 ± 0.03^a

(90.97)

1.02

6

89.09

1.06

5a

0.22 ± 0.02

(5.65)

0.21 ± 0.04

(23.08)

0.35 ± 0.04

(36.21)

0.25 ± 0.01^a,b

(54)

0.36 ± 0.05

(69.84)

0.13 ± 0.04^a,b

(79.42)

0.89

27

50.90

0.60

5b

0.23 ± 0.05

(8.70)

0.19 ± 0.04

(15.94)

0.38 ± 0.02

(29.50)

0.26 ± 0.05^a,b

(52.20)

0.24 ± 0.04^a,b

(61.90)

0.19 ± 0.01

(89.07)

1.010

18

67.27

0.80

5c

0.19 ± 0.06

(17.39)

0.44 ± 0.01

(36.50)

0.36 ± 0.01

(42.85)

0.37 ± 0.05

(55.36)

0.29 ± 0.02^a,b

(63.50)

0.22 ± 0.08^a

(89.54)

1.011

7

87.27

1.04

5d

0.21 ± 0.02

(6.19)

0.20 ± 0.02

(32.41)

0.26 ± 0.02

(23.47)

0.20 ± 0.03

(52.38)

0.40 ± 0.04

(59.61)

0.13 ± 0.004

(89.67)

1.012

8

85.45

1.02

6a

0.23 ± 0.02

(13.04)

0.21 ± 0.04

(19.23)

0.41 ± 0.01

(39.20)

0.37 ± 0.05

(43.56)

0.20 ± 0.07

(67.32)

0.36 ± 0.05

(91.08)

1.02

14

74.54

0.89

6b

0.37 ± 0.03

(11.15)

0.48 ± 0.08

(25.47)

0.32 ± 0.04

(48.89)

0.21 ± 0.02

(61.05)

0.21 ± 0.06

(71.08)

0.41 ± 0.01

(91.96)

1.03

8

85.45

1.02

7a

0.21 ± 0.02

(13.41)

0.44 ± 0.02

(17.31)

0.19 ± 0.04

(37.21)

0.22 ± 0.02

(51.31)

0.23 ± 0.02

(59.10)

0.36 ± 0.01

(61.24)

0.69

19

65.45

0.78

7b

0.22 ± 0.06

(11.35)

0.23 ± 0.07

(21.82)

0.41 ± 0.03

(19.07)

0.38 ± 0.02

(49.14)

0.19 ± 0.06

(61.24)

0.33 ± 0.02

(88.13)

0.99

11

80

0.95

8a

0.21 ± 0.03

(6.19)

0.20 ± 0.03

(27.81)

0.18 ± 0.06

(38.21)

0.21 ± 0.03

(40.11)

0.2 ± 0.08

(47.12)

0.34 ± 0.06

(56.02)

0.63

37

32.72

0.39

8b

0.14 ± 0.06

(7.41)

0.12 ± 0.06

(18.47)

0.32 ± 0.03^a

(22.46)

0.19 ± 0.04

(37.28)

0.33 ± 0.03

(43.62)

0.12 ± 0.06

(61.35)

0.69

33

40

0.47