Entry

BBB

Human

Intestinal absorption

P-glycogen inhibitor

CYP2C

19 inhibitor

hERG

Acute oral toxicity

Aqueous solubility

LogS

Rat acute toxicity LD₅₀

mol/kg

1

+0.5902

+0.9710

NI (0.9128)

NI (0.9479)

I (0.9358)

III (0.4665)

2.08

1.870

2

−0.6568

+0.9004

NI (0.6984)

NI (0.8216)

I (0.9707)

III (0.6016)

−3.15

2.017

3

+0.8789

+0.9839

I (0.7360)

I (0.6571)

I (0.9240)

III (0.6849)

−4.25

2.512

4

+0.8000

+0.9613

I (0.8787)

I (0.6571)

I (0.8923)

III (0.6849)

−4.25

3.010

5

+0.8356

+0.8570

I (0.8789)

I (0.6571)

I (0.9001)

III (0.6849)

−4.25

2.996

6

+0.8000

+0.9613

I (0.8191)

I (0.6970)

I (0.8265)

III (0.6849)

−4.00

2.961

7

+0.7500

+0.8961

NI (0.5403)

I (0.6800)

I (0.9389)

III (0.6612)

−3.50

2.129