External BNP calibrator

Mixture of BNP-32 and glycosylated proBNP

BNP-32 only

Glycosylated proBNP only

Low level^a

High level^b

Low level

High level

Low level

High level

Assigned standard concentration using the IRMA

37.7

158.9

35.8

181.5

36.4

181.8

Commercial lab 1

42.9

(0.88)

156.0

(1.02)

53.6

(0.67)

238.8

(0.76)

41.6

(0.88)

164.6

(1.10)

Commercial lab 2

23.6

(1.60)

103.3

(1.54)

22.9

(1.56)

85.2

(2.13)

26.6

(1.37)

126.8

(1.43)

MI02 Shionogi® BNP

28.0

(1.35)

138.1

(1.15)

37.6

(0.95)

187.8

(0.97)

36.6

(0.99)

197.5

(0.92)

Percentage of proBNP to total BNP (%)

62.2

80.3

n.t.

n.t.

n.t.

n.t.