| Number of Patients | Upon Enrollment | Three Years Later | P-value |
Group 1 (FREQ = 0) | 47 | 42.7 ± 11.9 | 46.6 ± 10.9 | 0.0008 |
Group 2 (FREQ = 1) | 63 | 42.6 ± 11.3 | 58.3 ± 8.2 | 0.0005 |
Group 3 (FREQ = 2) | 35 | 42.5 ± 11.5 | 67.9 ± 7.1 | 0.0004 |
Group 4 (FREQ = 3) | 18 | 42.5 ± 11.4 | 69.7 ± 9.5 | 0.0003 |
Group 5 (FREQ = 4) | 19 | 43.2 ± 11.2 | 78.7 ± 7.2 | 0.0001 |