Number of Patients

Upon Enrollment

Three Years Later

P-value

Group 1 (FREQ = 0)

47

42.7 ± 11.9

46.6 ± 10.9

0.0008

Group 2 (FREQ = 1)

63

42.6 ± 11.3

58.3 ± 8.2

0.0005

Group 3 (FREQ = 2)

35

42.5 ± 11.5

67.9 ± 7.1

0.0004

Group 4 (FREQ = 3)

18

42.5 ± 11.4

69.7 ± 9.5

0.0003

Group 5 (FREQ = 4)

19

43.2 ± 11.2

78.7 ± 7.2

0.0001