| Functional activitya | Protein | Molecular weight (kDa) | Keynotes related to cancer |
| Pro-cancer | C4b-bindingprotein | 67 | Protects cancer cells from complement activation & attack |
| ComplementC3 | 187 | Promotes cancer development & progression through various tumorigenic effects | |
| Complement factor H | 139 | Protects cancer cells from complement- mediated cytolysis | |
| Serotransferrin | 77 | Growth factor for cancer cell proliferation | |
| Vitronectin | 54 | Inducer of cancer cell differentiation, spreading, migration, & growth | |
| Anti-cancer | 35 kDa inter-α-tryps in Inhibitor heavy chain 4 | 104 | Down regulation leads to tumor initiation &progression in multiple solid tumors |
| Anastellin | 256 | Inhibits tumor growth & metastasis in-vivo | |
| ApolipoproteinA-1 | 31 | Suppresses tumor growth & metastasis in animaltumor models | |
| Fibrinogen β chain | 56 | β43-63 inhibits tumor vascularization in mouse models | |
| Keratintype I cytoskeletal9 | 62 | Down regulation is associated with increased drug resistance in breast cancer |